OK I think I found, by changing /usr/share/pipewire/pipewire.conf file, see below wiki :
https://gitlab.freedesktop.org/pipewire/pipewire/-/wikis/Config-PipeWire#setting-sample-rates
So now it seems my hardware issues are over 
In fact the audio-setting.toml contains settings for pipewire to change the rate and quantum size and they do work, although the sonic pi audio hardware settings do not change.
You can check by launching the command line utility pw-top with Sonic Pi running and you can see the quantum and sample rate settings for pipewire there. Under pipewire a wrapper pw-jack is played around the command that starts scsynth and this allows those adjusts for the pipewire settings.
I have raised an issue on github about this, as Iām uncertain what the overall latency settings are.
see the image below which shows the audio-settings.toml file, the output of pw-top and the audio data displayed by Sonic Pi.
